Fat Burner

Buy Fatburner with Ephedrine, Clenbuterol and T3 with guaranteed success.

What are fat burners?

Both products can contribute when you want to lose weight or when you want to dry-train.
Examples include caffeine, guarana, carnitine, ephedrine, synephrine, green tea, forskolin, ephedrine, 5-htp, ginger, red pepper.
Lose weight with fat burners

Eve...

Buy Fatburner with Ephedrine, Clenbuterol and T3 with guaranteed success.

What are fat burners?

Both products can contribute when you want to lose weight or when you want to dry-train.
Examples include caffeine, guarana, carnitine, ephedrine, synephrine, green tea, forskolin, ephedrine, 5-htp, ginger, red pepper.
Lose weight with fat burners

Every person has their own daily energy balance, consisting of: energy consumption and energy intake. Energy use is the amount of energy that the body needs to ensure that all body processes run smoothly and to enable, among other things, movement. This differs per person and also varies per gender. The average energy requirement of men who are moderately active is 2500kcal (kilocalories). The energy requirement of women who are moderately active is 2000kcal.

With the energy intake we mean all the energy that you get through your diet. If you absorb more energy over a long period than you burn, your body weight will increase. We then speak about a positive energy balance in this case. Suppose you do not take more energy but less energy than you use in the same long period of time, then you decrease in body weight. In that case we speak of a negative energy balance.

When you want to lose weight, the goal is to come out daily on a negative energy balance.Do not forget to look at your fat percentage. Many people are staring blindly at their weight while actually having a lower fat percentage.
Operation fat burners and stackers

As mentioned earlier, these supplements are a means to promote weight loss and dry training. This happens, among other things, because they stimulate the use of energy so that you can arrive at a negative energy balance sooner. A stacker acts as a fat burner and is a food supplement. Both products are widely used in the sports world.

The effect of a fat-burning dietary supplement such as a stacker has an influence on the process of thermogenisis, or the process that breaks down body fat. When the metabolism increases, thermogenisis will occur and the stored fat stores will be burned to provide energy for this increase in the metabolism. ">It also prevents the stock of fats from increasing.

An important aspect of using these types of supplements is still the daily diet. The big problem of many people using Stackers is that they often do not follow a good lifestyle. Because they do not eat healthy and exercise, it often happens that the action of the stackers is short-lived or not even noticeable. The so-called yo-yo effect then occurs. When someone stops the stackers, the person will arrive again soon, because the bad lifestyle is still being followed. The healthiest way to lose weight is therefore still exercising and following a good diet. In combination with a food supplement, this is a good way.
Buy Fatburners

On the basis of the above, do you want to try out fatburners and buy fat burners? The offer is huge and therefore the reviews and reviews on the products of all providers can help you make an informed choice:
Fatburners benefits

In fat-burning products often the same active substances are included which lead to an increased metabolism and a lower fat absorption.
Some of these examples are, of course, caffeine, the Ephedra, Green Tea extract and Guarana, which have since been banned in the Netherlands. What exactly do these substances do when they enter the body?
Caffeine

Of caffeine and the various products containing caffeine, such as energy drinks, it is known that it is a substance that can have a stimulating effect and that it can stimulate fat burning.The effect can be attributed to the fact that it stimulates the heartbeat and increases the metabolism. There are also disadvantages to the use of caffeine. Because caffeine stimulates the central nervous system, an overtraining effect could occur with prolonged use.
Ephedra

Ephedra sinica or ma huang is nowadays known as the basic ingredient of many herbal energizers, but has a long history as a health product. Already 2000 years ago it was used in Chinese health science, for example to relieve the respiratory tract, and to promote the metabolism.

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Fat Burner 12 products.

Subcategories

  • Ephedrine

    1. What is Ephedrine and what is it used for?
    Ephedrine belongs to a group of medicines called sympathomimetics.
    Sympathomimetics act on the part of the nervous system that controls automatic functions.
    Ephedrine is used to treat low blood pressure during spinal cord injection
    counteract. Ephedrine raises blood pressure by temporarily reducing blood flow to the small one
    Reduced blood vessels.

    2. What should you watch out for before giving Ephedrine?
    Ephedrine must not be used
    - if you are allergic (hypersensitive) to ephedrine hydrochloride or any of the substances mentioned in section 6.
    ingredients of this medicine
    - if you have hyperthyroidism, appetite increase, weight loss or sweating
    can cause
    - if you have an enlarged prostate
    - if you have heart disease
    - if you have an increased intraocular pressure (glaucoma)
    - if you have diabetes mellitus
    - if you have a thrombosis
    - if you have low blood pressure
    - if you are taking MAO inhibitors (monoamine oxidase inhibitors) (see application of
    Ephedrine with other medicines)
    - if you have high blood pressure.
    If any of the above applies to you, please inform your doctor.

    Use of ephedrine with other medicines
    Please inform your doctor or nurse if you are taking any other medicines
    ingest / use or have recently taken / used, even if it is not
    prescription medicines.
    Other medicines that may interact with ephedrine  include:
    - a certain type of antidepressants called MAO inhibitors (monoamine oxidase inhibitors)
    become. Tell your doctor or nurse, even if
    You have stopped taking a MAO inhibitor in the last two weeks;
    - cough and cold remedies;
    - Narcotics for inhalation, such as halothane;
    - medicines for the treatment of depression;
    - sibutramine, an appetite suppressant;
    - linezolid, a medicine used to treat infections;
    - medicines for the treatment of bronchial asthma such as theophylline;
    - Corticosteroids, a group of medicines used in different diseases
    To reduce swelling;
    - medicines for epilepsy;
    - Doxapram, a drug used to treat respiratory problems;
    Oxytocin, a medicinal product used in childbirth;
    - Medicines for the treatment of hypertension such as guanethidine.
    pregnancy and breast feeding period
    If you are pregnant or breastfeeding, or suspect you may be pregnant or intend to
    To get pregnant, ask your doctor for advice before being given this medicine.
    Driving and using machines
    Ephedrine  will not affect the ability to drive or to drive
    Machines expected. However, if you feel unwell, first ask your doctor before returning
    start to drive a vehicle or operate machinery.
    laboratory tests
    This medicine contains an active substance that may give positive results in doping controls.

    3. How to administer Ephedrine?
    This is a medicine for injection that is given to you by your doctor. Your doctor will too
    Determine the dose you need.

    Adult and older patients:
    The usual starting dose is 3-7.5 mg as a slow injection into a vein. The injection will be yours
    may be repeated once or several times until you reach the maximum dose of the drug (30 mg)
    have received.
    Patients with kidney or liver dysfunction:
    There are no special dosage recommendations for patients with kidney or kidney dysfunction
    Liver.

    Children:
    Ephedrine  30 mg / ml, concentrate for solution for injection, is not recommended for
    Use in children due to inadequate safety and safety data and Dosage recommendations.

    If you suspect you have received too much Ephedrine
    This medicine will be given to you by your doctor and therefore it is unlikely that you will
    much of it received. Your doctor is aware of how an overdose is detected and treated.
    If you are worried about your treatment, talk to your doctor.
    If you have any further questions on the use of the medicine, contact your doctor or the
    medical professionals.

    4. What side effects are possible?
    Like all medicines, ephedrine  may cause side effects, although not everybody gets them
    have to.

    Frequently:
    - confusion, concern, depression
    - nervousness, irritability, restlessness, weakness, insomnia, headache, sweating, anxiety
    - Increased perception of the heartbeat (palpitations), high blood pressure, rapid heartbeat
    - shortness of breath
    - nausea, vomiting.
    Rare:
    - Irregular heartbeat
    - Problems urinating.
    Other side effects (how often these are not known):
    - influence on blood clotting
    - allergy
    - Changes in personality or emotional or mental world, fear
    - tremors, excessive salivation
    - increased pressure in the eye (glaucoma)
    - Pain over the heart, slow heartbeat, heart failure (cardiac arrest), lower
    blood pressure
    - Bleeding in the brain
    - breathing problems
    - Appetite reduction
    - decrease in potassium content in the blood, change in blood sugar levels
    - Fluid accumulation in the lungs (pulmonary edema).

    Overdose with this medicine may cause you to:
    - see or hear things that are not there (hallucinations)
    - believe things that do not apply (delusions)
    - notice changes in your personality or your emotional or mental world.
    If you notice any side effects, consult your doctor or nurse.
    This also applies to side effects not listed.

    5. How to store Ephedrine?
    Keep this medicine out of the sight and reach of children.
    This medicine may be given after the label and the carton after "EXP" respectively
    "Usable until" specified expiration date can no longer be administered. The expiry date relates
    on the last day of the given month.
    This medicinal product does not require special storage conditions.

    Do not dispose of medicines in wastewater. Ask your pharmacist how to take the medicine
    dispose of when you stop using it. You help to protect our environment.

  • Clenbuterol

    1. What are Clenbuterol tablets and what are they used for?

    Clenbuterol tablets contain as an active ingredient Clenbuterolhydrochlorid, which is Asthma bronchial and bronchitis the cramped airways extended and so the respiration Facilitates.

    Clenbuterol tablets are used for symptomatic treatment chronic Obstructive respiratory diseases with respiratory constriction, such as asthma bronchial or chronic obstructive bronchitis with and without emphysema.

    2. What do you need to consider before taking Clenbuterol tablets?

    Clenbuterol tablets may not be taken,

    • If you are hypersensitive (allergic) to Clenbuterol or any of the other stock

    • If you are under a severe overfunction of the thyroid gland, irregular and Accelerated Heartbeat (Tachykarde arrhythmia) and heart muscle augmentation (Hyper-Strikes obstructive cardiomyopathy).

    In the case of rare congenital incompatibilities with any of the other constituents.

    3. How to take Clenbuterol tablets?

    Always take Clenbuterol tablets exactly according to the doctor's instructions. Please check with your doctor or pharmacist if you are not sure.

    If the doctor does not prescribe otherwise, the usual dose is:

    Adults and children from 12 years in the morning and in the evening 1 tablet.

    In the course of a longer treatment, the dose can often be reduced to 2 x ½ tablets daily.

    In case of more respiratory problems, the treatment may be on the first 2-3 days with up to 2 x 2 tablets started daily and after the occurrence of a lasting improvement with

    Reduced dose is continued.

    Please take the Clenbuterol tablets whole at meals with sufficient liquid-

    (preferably a glass of drinking water). Do not take Clenbuterol tablets

    4. How to store Clenbuterol tablets?

    Keep medicines out of the reach of children!

    You may use the medicine according to the on the folding box after "usable until"

    No longer use the specified expiration date. The expiration date refers to the

    To the last day of the month.

    Storage conditions of Clenbuterol

    Do not store over 25 °c. In the original packaging to prevent the contents from being to protect light.

    The medicinal product must not be disposed of in wastewater. Ask your pharmacies

    How to dispose of the medicine when you no longer need it. This

    Action helps to protect the environment.

  • Liothyronine Sodium T3

    Applications of T3 (liothyronine sodium)
    - Hypothyroidism, such as:
    - inherited or acquired thyroid damage by e.g. Surgery, radiation or medication (primary thyroid hormone deficiency)
    - Thyroid damage due to dysregulation in the brain areas pituitary or hypothalamus (secondary thyroid hormone formation weakness)
    - benign goiter (goiter), with normal (euthyroid) thyroid function
    - Prevention of recurrence of goiter (goiter), with normal (euthyroid) thyroid function
    - Thyroid cancer, especially after surgery

    Contraindications of T3 (liothyronine sodium)
    Describes which illnesses or circumstances speak against the use of the drug, in which age groups the drug should / should not be used and if pregnancy and lactation speak against the use of the drug.
    What speaks against an application?

    Always:
    - Hypersensitivity to the ingredients
    - Acute myocardial infarction

    Under certain circumstances - talk to your doctor or pharmacist:
    - High blood pressure
    - cardiac arrhythmia with accelerated pulse (tachycardia)
    - heart failure
    - coronary heart disease (circulatory disorders of the heart muscle)
    - angina pectoris
    - Arteriosclerosis (arteriosclerosis)
    - Adrenocortical diseases, e.g. underactive
    Pituitary diseases, e.g. underactive
    - Hyperthyroidism, such as:
    - thyroid autonomy (certain form of hyperthyroidism)

    Which age group should be considered?
    - Children under 4 years: No dosage information available for this age group.

    What about pregnancy and lactation?
    - Pregnancy: According to current knowledge, the drug has no harmful effects on your child's development or childbirth.
    - Breast-feeding: According to current information, there are no indications that the medicinal product must not be used during breast-feeding.

    If the product has been prescribed despite a contraindication, talk to your doctor or pharmacist. The therapeutic benefit may be greater than the risk associated with the use of a counter-indication.
    side effects
    Side effects of T3 (liothyronine sodium)
    Side effects are undesirable effects that may occur if the product is used as intended.
    What adverse effects may occur?

    For the drug, only side effects are described that have so far occurred only in exceptional cases.

    If you notice a disability or change during treatment, consult your doctor or pharmacist.

    For the information provided at this point, particular consideration is given to side effects that occur in at least one out of every 1,000 patients treated.
    Important instructions
    Important notes about T3 (liothyronine sodium)
    Advice on the areas of allergies (concerning active ingredients and excipients), interactions, complications with food and beverages, as well as other warnings.
    What should you pay attention to?
    - Beware of allergy to iodine!
    - Beware of allergy to binders (eg carboxymethylcellulose with E number E 466)!
    - Beware of intolerance to lactose. If you have to follow a diabetes diet, you should consider the sugar content.
    - There may be medicines that interact with. Therefore, you should always tell the doctor or pharmacist about any other medicine that you are already using before you start treatment with a new medicine. This also applies to medicines that you buy yourself, use only occasionally or have been used for some time.

    interactions
    interactions

    If several drugs are used at the same time, interactions may occur. Effects and side effects of the drugs can be changed. Whether an interaction occurs depends on various factors.
    Always talk to your doctor or pharmacist to determine if an interaction really does matter to you. Only a doctor or pharmacist can estimate your individual risk factors for an interaction. If necessary, the doctor or pharmacist can take appropriate action. Do not stop taking medicines prescribed by your doctor without consulting your doctor or pharmacist.

    Dosage and instructions for use


    Dosage of T3 (liothyronine sodium)
    How is the drug dosage?

    The following dosage recommendations are given - the dosage for your specific illness should be discussed with your doctor:

    In hypothyroidism:

    Children from 4-12 years
    Single / total dose: 1 / 2-1 tablet / once daily
    Time: before the first meal (about 30 minutes)

    Teenagers from 12 years and adults
    Single / total dose: 1 / 2-2 tablets / once a day
    Time: before the first meal (about 30 minutes)

    For benign goiter and for prophylaxis after surgery:

    Teenagers from 12 years and adults
    Single / total dose: 1 / 2-1 tablet / once daily
    Time: before the first meal (about 30 minutes)

    Thyroid cancer, especially after surgery:

    Teenagers from 12 years and adults
    Single / total dose: 1-2 tablets / once a day
    Time: before the first meal (about 30 minutes)

    Elderly and debilitated patients: You may need to reduce the single dose in consultation with your doctor.
    application Notes
    Describes the correct use of the medicine and how long the medicine should / should be used.
    The total dose should not be exceeded without consulting a doctor or pharmacist.

    Type of application?
    Take the medicine with liquid (for example, 1 glass of water).

    Duration of application?
    The duration of use depends on the type of complaint and / or duration of the disease and is therefore determined only by your doctor. In hypothyroidism: mostly lifelong; for prophylaxis and normal (euthyroid) thyroid function: months to lifelong.

    Overdose?
    It can cause a variety of overdose symptoms, including anxiety, agitation and arrhythmia with accelerated heart rate. If you suspect an overdose, contact a doctor immediately.

    Forget about taking?
    Continue to take the intake at the next prescribed time as normal (ie not twice the amount).

    In general, pay attention to a conscientious dosage, especially in infants, toddlers and the elderly. If in doubt, ask your doctor or pharmacist for any implications or precautions.

    A dosage prescribed by the doctor may differ from the information on a package leaflet. Because the doctor will tailor them individually, you should use the medicine as directed.

  • Sibutramine

    What is Sibutramine?

    Sibutramine is a chemical substance of the amphetamine type with strong fatburning properties. Proofen effective by thousands of people worldwide, sibutramine is here to slim trim and make obesity a thing of the past. Also known under tradenames like Reductil, Meridia, Reduce and many more it revolutionized the world of fatburning and started another level of targeted fatrburning of typical problem zones of the human body.

    Reductil (sibutramine hydrochloride monohydrate) is an orally administered agent for
    the treatment of obesity. Chemically, the active ingredient is a racemic mixture of the
    (+) and (-) enantiomers of cyclobutanemethanamine, 1-(4-chlorophenyl)-
    N, N-dimethyl-
    α-(2-methylpropyl)-, hydrochloride, monohydrate, and has an empirical formula of
    C
    17H29CI2NO. Its molecular weight is 334.33.

    Sibutramine hydrochloride monohydrate is a white to cream crystalline powder with a
    solubility of 2.9 mg/mL in pH 5.2 water. Its octanol:water partition coefficient is 30.9 at
    pH 5.0.

    Mechanism of action

    Sibutramine produces its therapeutic effects by norepinephrine, serotonin and
    dopamine reuptake inhibition. Sibutramine and its major pharmacologically active
    metabolites (M
    1 and M2) do not act via release of monoamines.

    Sibutramine exerts its pharmacological actions predominantly via its secondary (M1)
    and primary (M
    2) amine metabolites. The parent compound, sibutramine, is a potent
    inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine reuptake
    in vivo,
    but not
    in vitro. However, metabolites M1 and M2 inhibit the reuptake of these
    neurotransmitters both
    in vitro and in vivo.
    In human brain tissue, M
    1 and M2 also inhibit dopamine reuptake in vitro, but with
    about 3-fold lower potency than for the reuptake inhibition of serotonin or
    norepinephrine.

    A study using plasma samples taken from sibutramine-treated volunteers showed
    monoamine reuptake inhibition of norepinephrine > serotonin > dopamine; maximum
    inhibitions were norepinephrine = 73%, serotonin = 54% and dopamine = 16%.
    Sibutramine and its metabolites (M
    1 and M2) are not serotonin, norepinephrine or
    dopamine releasing agents. Following chronic administration of sibutramine to rats, no
    depletion of brain monoamines has been observed.
    Sibutramine, M
    1 and M2 exhibit no evidence of anticholinergic or antihistaminergic
    actions. In addition, receptor binding profiles show that sibutramine, M
    1 and M2 have
    low affinity for serotonin (5-HT
    1, 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C), norepinephrine (β, β1,
    β3, α1 and α2), dopamine (D1 and D2), benzodiazepine, and glutamate (NMDA)
    receptors. These compounds also lack monoamine oxidase inhibitory activity
    in vitro
    and in vivo.

    Pharmacokinetics

    Absorption
    Sibutramine is rapidly absorbed from the gastrointestinal [GI] tract (Tmax of 1.2 hours)
    following oral administration and undergoes extensive first-pass metabolism in the liver
    (oral clearance of 1750 L/h and half-life of 1.1 h) to form the pharmacologically active
    mono- and di-desmethyl metabolites M
    1 and M2. Peak plasma concentrations of M1 and
    M
    2 are reached within 3 to 4 hours. On the basis of mass balance studies, on average,
    at least 77% of a single oral dose of sibutramine is absorbed. The absolute
    bioavailability of sibutramine has not been determined.

    Effect of Food


    Administration of a single 20 mg dose of sibutramine with a standard breakfast
    resulted in reduced peak M
    1 and M2 concentrations (by 27% and 32%, respectively)
    and delayed the time to peak by approximately 3 hours. However, the AUCs of M
    1 and
    M
    2 were not significantly altered.

    Special Population


    Geriatrics

    Plasma concentration of M1 and M2 were similar between elderly (ages 61 to 77 yr)
    and young (ages 19 to 30 yr) subjects following a single 15-mg oral sibutramine dose.
    Plasma concentrations of the inactive metabolites M
    5 and M6 were higher in the elderly;
    these differences are not likely to be of clinical significance.
    In general, dose selection for an elderly patient should be cautious, reflecting the
    greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant
    disease or other drug therapy.

    Pediatric

    The safety and effectiveness of sibutramine in pediatric patients under 16 years old
    have not been established.

    Gender

    Pooled pharmacokinetic parameters from 54 young, healthy volunteers (37 males
    and 17 females) receiving a 15-mg oral dose of sibutramine showed the mean C
    max
    and AUC of M1 and M2 to be slightly <19% and <36%, respectively) higher in females
    than males. Somewhat higher steady-state trough plasma levels were observed in
    female obese patients from a large clinical efficacy trial. However, these differences are
    not likely to be of clinical significance.
    Dosage adjustment based upon the gender of a patient is not necessary.

    Race

    The relationship between race and steady-state trough M1 and M2 plasma
    concentrations was examined in a clinical trial in obese patients. A trend towards
    higher concentrations in Black patients over Caucasian was noted for M
    1 and M2.
    However, these differences are not considered to be of clinical significance.

    Hepatic Insufficiency
    In 12 patients with moderate hepatic impairment receiving a single 15-mg oral dose
    of sibutramine, the combined AUCs of M
    1 and M2 were increased by 24% compared to
    healthy subjects, while M
    5 and M6 plasma concentrations were unchanged. The
    observed differences in M
    1 and M2 concentrations do not warrant dosage adjustment in
    patients with mild to moderate hepatic impairment.
    Sibutramine should not be used in patients with severe hepatic dysfunction.

    Renal Insufficiency
    The effect of renal disease has not been studied. However, since sibutramine and its
    active metabolites M
    1 and M2 are eliminated by hepatic metabolism, renal disease is
    unlikely to have a significant effect on their disposition. Elimination of the inactive
    metabolites M
    5 and M6, which are renally excreted, may be affected in this population.
    Sibutramine should not be used in patients with severe renal impairment.

    Clinical Studies
    Observational epidermiologic studies have established a relationship between
    obesity and the risks for cardiovascular disease, non-insulin dependent diabetes
    mellitus (NIDDM), certain forms of cancer, gallstones, certain respiratory disorders, and
    an increase in overall mortality. These studies suggest that weight loss, if maintained,
    may produce health benefits for some patients with chronic obesity who may also be at
    risk for other diseases.
    The long-term effects of sibutramine on the morbidity and mortality associated with
    obesity have not been established. Weight loss was examined in 11 double-blind,
    placebo-controlled obesity trials with study durations of 12 to 52 weeks and doses
    ranging from 1 to 30 mg once daily. Weight was significantly reduced in a dose-related
    manner in sibutramine-treated patients compared to placebo over the dose range of
    5 to 20 mg once daily. In two 12-month studies, maximal weight loss was achieved by
    6 months and statistically weight loss was maintained over 12 months. The amount of
    placebo-substracted weight loss achieved on sibutramine was consistent across
    studies.
    Analysis of the data in 3 long term (>6 months) obesity trial indicates that patients
    who lose at least 4 pounds in the first 4 weeks of therapy with a given dose of
    sibutramine are most likely to achieve significant long-term weight loss on that dose of sibutramine.

    Approximately 60% of such patients went on to achieve a placebosubtracted weight loss of > 5% of their initial body weight by month 6. Conversely, of those patients on a given dose of sibutramine who did not lose at least 4 pounds in the
    first 4 weeks of therapy, approximately 80% did not go on to achieve a placebo substracted weight loss of > 5% of their initial body weight on that dose by month 6.
    Significant dose-related reductions in waist circumference, an indicator of intra abdominal fat, have also been observed over 6 and 12 months in placebo-controlled clinical trials.

    In a 12-week placebo-controlled study of non-insulin dependent diabetes
    mellitus patients randomized to placebo or 15 mg per day of sibutramine, Dual Energy
    X-Ray Asorptiometry (DEXA) assessment of changes in body composition showed that
    total body fat mass decreased by 1.8 kg in the sibutramine group versus 0.2 in the
    placebo group (p<0.001). Similarly, truncal (android) fat mass decreased by 0.6 kg in
    the sibutramine group versus 0.1 kg in the placebo group (p<0.01). The changes in
    lean mass, fasting blood sugar, and HbA
    1 were not statistically different between the
    two groups.
    Eleven double-blind, placebo-controlled obesity trials with study durations of 12 to
    52 weeks have provided evidence that sibutramine does not adversely affect glycemia,
    serum lipid profiles, or serum uric acid in obese patients. Treatment with sibutramine
    (5 to 20 mg once daily) is associated with mean increases in blood pressure of 1 to
    3 mm Hg and with mean increases in pulse rate of 4 to 5 beats per minute relative to
    placebo. These findings are similar in normotensives and in patients with hypertension
    controlled with medication. Those patients who lose significant (> 5% weight loss)
    amounts of weight on sibutramine tend to have smaller increases in blood pressure
    and pulse rate.


    In all Studies, sibutramine produced significant reductions in weight.                                              In two 1-year studies, maximal weight loss was achieved by 6 months and                                       statistically significant weight loss was maintained over 12 months.

    Sibutramine- induced weight loss has been accompanied by beneficial changes in
    serum lipids that are similar to those seen with nonpharmacologically-mediated weight
    loss.

    Sibutramine induced weight loss has been accompanied by reductions in serum uric
    acid. In one study, serum uric acid has been identified as an independent risk factor for
    death from coronary artery disease.

    Contraindications

    Reductil is contraindicated in patients with hypersensitivity to sibutramine or to any
    other ingredient of the preparation.
    Reductil is contraindicated in patients receiving monoamine oxidase inhibitors
    (MAOIs).
    Reductil is contraindicated in patients who have anorexia nervosa.
    Reductil is contraindicated in patients taking other centrally acting appetite
    suppressant drugs.

    The duration of treatment is limited to one year.
    Treatment with sibutramine should only be given as part of an integrated therapeutic
    approach for weight reduction under care of a physician experienced in the treatment
    of obesity. An appropriate approach to obesity management should include dietary and
    behavioral modifications as well as increased physical activity. This integrated
    approach is essential for a lasting change in eating habits and behavior which is
    fundamental to the long-term maintenance of the reduced weight level once therapy is
    complete.


    Blood Pressure and Pulse

    SIBUTRAMINE SUBSTANTIALLY INCREASES BLOOD PRESSURE. REGULAR MONITORING OF BLOOD PRESSURE IS REQUIRED WHEN USING SIBUTRAMINE.

    Dosage and Administration

    The recommended starting dose of Reductil is 10 mg administered once daily in the
    morning swallowed whole with a glass of water. The capsule can be taken with or
    without food. If there is inadequate weight loss, the dose may be titrated after 4 weeks
    to a total of 15 mg once daily.

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Showing 1 - 12 of 12 items